三年前，李毅的妻子被人杀害后，他隐姓埋名追查凶手。但可惜，三年来始终毫无线索。三年后，李毅的好友周新终于帮他查到杀妻凶手的姓名，但就在两人见面时，周新却被神秘杀手暗杀。临死前，周新交给李毅一个盒子。锦衣卫指挥使纪纲是这次暗杀的主谋，在他得知李毅拿走了关键证据后，转而追杀李毅。另一方面，锦衣卫同知（副指挥使）曹坚也在调查周新死因时将目标锁定在头号嫌疑人李毅身上。站在风口浪尖上的李毅只得一边躲避着纪纲的追杀和曹坚的追捕，一边费尽心血寻找杀妻凶手。
在一个隐秘的脱衣舞俱乐部里，围聚着一群异形生物和一个变节的联邦警员，这些异形生物以人血为食，它们的攻击带有奇特的麻醉作用；联邦警员身份特殊，手上附着生物芯片……他们同时出现有一个原因：那就是带有生物作用的药品已出现在俱乐部里……
Kyohei Aizawa, an assassin for a covert non-governmental espionage group in Japan called "SEEK", is grieving over the loss of his girlfriend from a tragic plane accident. The leader of "SEEK",Ryo Mikumo, contacts him for an emergency mission; save a fellow agent, recover a new highly explosive liquid called "RDX@", stop a ruthless Yakuza leader, Sojiro Kotsuki, and his gang before they take over Japan. Although the Ninjas were thought to have disappeared... the new breed of assassins live on helping to protect Japan and all that is right; the Ninjas are coming soon.
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